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Cardiovascular disease (CVD) is the number one overall cause of mortality in the United Stated (U.S.) and in other industrialized countries. An attempt has been made to include an advocacy on Heart healthy changes for men concerned about prostate cancer because it places probability and the overall research into perspective. Lifestyle factors that promote CVD also appear to increase prostate cancer risk and those that reduce CVD risk also appear to reduce the risk of prostate cancer. The largest randomized trials utilizing dietary supplements or pharmacologic agents for prostate cancer prevention (Selenium and Vitamin E Cancer Prevention Trial [SELECT]) have also shed light on the problems and future solutions in this area. In addition, over exposure to specific anti-oxidants in nutritionally replete populations may be encouraging cancer growth. It is also interesting that statins, aspirin, and/or metformin (S.A.M.) are 3 generic, low-cost, heart healthy agents derived from natural sources with separate mechanism of actions, which all appear to have the best benefit to risk ratio compared to any other agent available for prostate cancer prevention, especially aggressive disease, or as an ancillary agent (s) to conventional cancer treatment. …. Dr. H. K. Saboowala.