LIVRO “At a Glance – HDL The good, but complex, cholesterol.” (English Edition) PDF Dr.Hakim Saboowala.



Epidemiological studies clearly show that levels of high-density lipoprotein cholesterol (HDL-C) are inversely associated with the risk of coronary artery disease and its thrombotic complications. However, in a recent study, researchers tested the hypothesis that increased plasma HDL-C is protective for myocardial infarction (MI) by examining the relationship between genetic variations associated with elevated levels of plasma HDL-C and the risk of MI. The major approach used is Mendelian randomization, a method developed to infer disease causality of a genetic variation. An attempt has been made to include, in this Booklet, several evidence-based research works done by leading researchers, as recently, they have challenged this assumption by showing that genetically elevated HDL-C did not protect against myocardial infarction. This finding has fueled a lively discussion in the lay, scientific, and medical press about the relationship between HDL-C and HDL function, and the potential effectiveness of various HDL-C raising strategies……….Dr.H.K.Saboowala